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MADRID, Spain -- The slippery blue clay may be gone, but the Madrid Open continues to produce surprises. Second-ranked Roger Federer was ousted by Kei Nishikori of Japan 6-4, 1-6, 6-2 in Thursdays third round, leaving Rafael Nadal as the either the clear front-runner for the title or the next big name who should be wary of an upset. Nadal didnt let his sore knee get in the way of downing Mikhail Youzhny 6-2, 6-3 to reach a quarterfinal with David Ferrer, while third-seeded Andy Murray had to come from behind to edge past Giles Simon 2-6, 6-4, 7-6 (6). "Clearly the favourite for this tournament is Nadal," Federer said. Serena Williams and Maria Sharapova -- the top two seeded women-- also reached the quarters in straight sets. Last year, Federer didnt let the slick "Smurf-colored" clay stop him from winning his third title in Madrid. But now with the old-fashioned red clay back at the Caja Magica, Federer only managed to look like the star he is for a spell. Yet Federer wasnt the first highly-ranked player to fall. World No. 1 Novak Djokovic was ousted on Tuesday, a day before Victoria Azarenka followed in a temper tantrum. After recovering from Nishikoris strong start, Federer looked like hed found his stride as he roared back in the second set. But Nishikori reasserted his ground game in the decider, after breaking Federer for a 3-1 advantage, and held on for the surprising victory. Nishikori said beating Federer after losing their only previous meeting was one of the high points of his still burgeoning career. "He was my idol and to beat him was one of the goals for my tennis career," the 16th-ranked Nishikori said. "Beating Roger is, yeah ... I need a couple of days to celebrate." Federer came to Madrid after a seven-week layoff. He said the gusting winds hurt his game, but he gave all credit to Nishikori. "He was the better player today for sure," Federer said. "I was lacking control from the baseline and that carried through from start to finish. Overall Im disappointed with my play." Federer said he will not change his plans and will now train for Rome and then the French Open. This was Nishikoris fourth win over a top-five opponent. Nishikori will next play Pablo Andujar, who advanced when fellow Spaniard Daniel Gimeno-Traver retired. Nadals commanding win over Youzhny featured an array of winning shots. Having already established control by stealing Youzhnys second service game, Nadal kept a point alive with a deft no-look backhand flick before nailing a winner down the line to hold his serve and delight his fans. The fifth-ranked Spaniard then broke Youzhny again by dinking the ball over the net while on the run, giving it so much backspin it twisted away from the Russian. Nadal, who is searching for his seventh straight final since returning from injury, improved to 28 wins and two losses on the year. Nadal said he was still bothered by his left knee, which has sidelined him this year with a nagging case of tendinitis. "Sometimes I have pain," Nadal said. "I try to avoid talking about it as much as possible. With respect to my rivals its not the moment to analyze how I am." Nadals next opponent, Ferrer, outlasted Tommy Haas 7-5, 4-6, 6-4. Murray looked stiff as he conceded the first set to Simon but the Scot improved, and after winning a long game to break back early in the second set, slowly imposed his will. Even so, he squandered five match points before Simon netted his final approach shot in the tiebreaker to end the match in just under three hours. Murray will play Tomas Berdych, who defeated Kevin Anderson of South Africa 7-6 (5), 7-5, to make the final eight. Also, Jo-Wilfried Tsonga beat Fernando Verdasco of Spain 4-6, 6-3, 6-2 to set up a match with Stanislas Wawrinka, who came back to see off Grigor Dimitrov 3-6, 6-4, 6-1. On the womens side, the top-ranked Williams dispatched Maria Kirilenko 6-3, 6-1, after Sharapova put away Germanys Sabine Lisicki 6-2, 7-5. Williams dominant performance made Kirilenko wither after she dropped the first set with one of several unforced errors. "I just felt really relaxed, like I was taking my time," said Williams, adding that she strived for precision over speed on serve. Williams will take on local favourite Anabel Medina Garrigues, who advanced after Yaroslava Shvedova of Kazakhstan withdrew with a right arm injury. Sharapova will face Kaia Kanepi of Estonia next after she defeated Daniela Hantuchova of Slovakia 6-3, 6-4. Ekaterina Makarova of Russia beat Marion Bartoli 6-3, 6-2 and will play Sara Errani following her 7-5, 6-3 win over Varvara Lepchenko. Angelique Kerber of Germany meets former No. 1 Ana Ivanovic. Erik McCoy Jersey . He said Tuesday thats a big reason why he is now the new coach of the Tennessee Titans. 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The Buffalo Bills placed wide receiver Sammy Watkins on injured reserve Friday as he continues to battle an ailing foot.The IR designation means Watkins will be out of game action a minimum of eight weeks.The move came hours after coach Rex Ryan expressed concern that the injury could linger.I dont know if fear is the right word, but major concern, Ryan told reporters.Watkins is scheduled to fly to North Carolina this week to meet with Dr. Robert Anderson to determine if he needs a second surgery that would end his season, a source told ESPNs Adam Schefter on Sunday.Watkins had offseason surgery to repair a broken bone in the foot, and soreness has lingered. He did not play in Sundays win against the Arizona Cardinals, and he did not participate in practice this week.I dont mind doing this every week, Ryan said earlier Friday, before the wideout was placed on IR. If Sammy can play, then obviously we want him out there. But if this is something that is hurting this young man in any way, shaape or form, then absolutely I dont want him out there.dddddddddddd.Watkins is eligible to return to practice Nov. 11. The earliest he can play is Nov. 27 against the Jacksonville Jaguars. If he does return to practice, the Bills have 21 days to activate him or keep him on IR.In a corresponding move, the Bills announced that they have claimed veteran wideout Justin Hunter.Watkins has not been available in the locker room or spoken to reporters since Sept. 19, when he said his foot injury was kind of out of the window, adding, I know what